Am I mad to consider using .Net2 and AJAX for a high-scalability application? In case you wonder why, it's the legacy of a website built on IIS and .Net 1.1, and we're looking for ways to make the content more attractive and interactive. In this case, it's a medical image library being shared by a few Wikis and online coursework for medical students ( < 15K users) and doctors ( < 150K users) But I'm worried about the performance overhead. We already have a performance problem because of personalising the content for users according to their type (student or doctor), and for doctors, their grade and speciality.