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This is a useful post by Frank Mashraqi, Director of Business Operations & Technical Strategy for a top 50 website that delivers billions of page views per month.
Since scalability is considered a non-functional requirement, it is often overlooked in the hopes of decreasing time to market. Adding scalability down the road can decrease the time to market but only after assuming significant technical debt.
Balancing performance and scalability vs. fast iteration and cost efficiency can be a significant challenge for startups. The good news is that achieving this balance is not impossible.
Read the rest of the article here and view a presentation here.